Postdoctoral Fellow, Scientist, or graduate student in human whole-cell modeling

About the Karr Lab

Despite the explosion of data, we do not understand the details of how phenotype arises from genotype and the environment. We are developing whole-cell computational models which aim to comprehensively predict how cell behavior emerges from the molecular level by representing all of the biochemical activity inside cells. Our goal is to use whole-cell models to transform bioengineering and medicine into rigorous, quantitative disciplines. For example, whole-cell models could enable bioengineers to design microbial genomes for a variety of industrial applications, as well as enable physicians to tailor medical therapy to individual patients. Our research is highly interdisciplinary, involving systems biology, genomics, bioinformatics, data integration, numerical simulation, software engineering, and data visualization, and team-oriented.

About the Institute for Genomics & Multiscale Biology and the Icahn School of Medicine at Mount Sinai

The Karr Lab is a member of the Icahn Institute for Genomics & Multiscale Biology at the Icahn School of Medicine at Mount Sinai . The Icahn Institute aims to bring genomic technologies together with computational analyses to discover new disease mechanisms, develop new diagnostics, and identify new drug targets. The institute is a collaborative and interdisciplinary environment.

The Icahn School of Medicine at Mount Sinai is a superb environment for translational research and training. The school's multidisciplinary research institutes foster seamless collaboration with clinicians.


The scientist will help develop the first whole-cell model of a human embryonic stem cell and use the model to gain insights into pluripotency maintenance among other fundamental cell behaviors. This will include aggregating and organizing experimental data to build models, designing models, calibrating models, validating models, analyzing simulation results, and using models to generate new hypotheses. The scientist will also have opportunities to contribute to the development of new whole-cell modeling methods and software tools.

Desired skills/experience

Whole-cell modeling is highly interdisciplinary. Consequently, we are looking for teammates with a broad range of relevant experience for cell modeling.

  • Passion for transforming bioengineering and medicine through modeling;
  • Desire to tackle challenging problems;
  • Commitment to innovation;
  • Abilities to think creatively, integrate diverse concepts, and push past barriers;
  • Experience in dynamical and/or genome-scale modeling;
  • Knowledge of cell biology, genomics, mathematics, and computer programming;
  • Excellent oral and written communication skills;
  • Abilities to work independently and within a team; and
  • BS, MS, or PhD in computational biology or related field.

Career development, recreation, benefits, and compensation

Mount Sinai offers numerous opportunities for career development, as well as competitive benefits. Compensation will be commensurate with experience. Please see the links below for more information.

  • Staff
    • Benefits
    • Recreation programs
  • Postdoctoral scholars
    • Career development programs
    • Benefits
    • Subsidized housing
    • Recreation programs
  • Graduate students
    • PhD programs
    • Student organizations
    • Recreation programs
    • Subsidized housing

How to apply

Postdoctoral fellows and staff: Email a cover letter and CV to Jonathan .

Graduate students: Email a cover letter and CV to Jonathan , and apply to one of Mount Sinai's graduate programs . PhD applications are due December 1 each year to start the following September.

Undergraduate students: Email a cover letter and CV to Jonathan and, if eligible, apply to the Mount Sinai Summer Undergraduate Research Program .

Mount Sinai Medical Center is an equal opportunity/affirmative action employer.

More information

Please contact Jonathan .