About the Karr Lab
Despite the explosion of experimental data, we do not understand the details of how phenotype arises from genotype and the environment. We are developing whole-cell computational models which comprehensively predict how cell behavior emerges from the molecular level by representing all of the biochemical activity inside cells. Our goal is to use whole-cell models to transform bioengineering and medicine into rigorous, quantitative disciplines. For example, we believe that whole-cell models could enable bioengineers to design microbial genomes for a variety of industrial applications, as well as enable physicians to tailor medical therapy to individual patients. Our research is highly interdisciplinary, involving systems biology, genomics, bioinformatics, data integration, parallel simulation, optimization, software engineering, and data visualization, and highly team-oriented.
About the Institute for Genomics & Multiscale Biology and the Icahn School of Medicine at Mount Sinai
The Icahn Institute for Genomics & Multiscale Biology is a leader in basic and translational genomic and computational biology research. The institute's multidisciplinary researchers bring state-of-the-art genomic technologies together with advanced computational analyses to discover new disease mechanisms, develop new diagnostics, and identify new drug targets. The institute is a highly collaborative and interdisciplinary environment. Please see the institute's website for more information.
The Icahn School of Medicine at Mount Sinai is a world leader in translational medicine. The school's multidisciplinary research institutes foster collaboration along a seamless continuum from the laboratory to patient care. State-of-the-art laboratories support groundbreaking research, and abundant clinical venues offer superb patient care and training.
The student will help develop detailed computational models of individual cells. This will include aggregating and organizing data; designing, testing, and calibrating models; and developing software tools to enable researchers to build more comprehensive and more predictive models. The student will also have opportunities to participate in group meetings and attend seminars. The candidate will work closely with Prof. Karr or one of our postdoctoral fellows.
Whole-cell modeling is a highly interdisciplinary problem. Consequently, we're looking for team members with a broad range of skills. The ideal candidate has the following skills. Students with related experience are also encouraged to contact Jonathan.
- Majoring in systems biology, computational biology, bioinformatics or a related field;
- Strong interest in computational modeling;
- Broad knowledge of biology and computer programming; and
- Abilities to solve challenging problems.
Dates and duration
Start and end dates are flexible. Summer internships should last 8-12 weeks and winter internships should last 3-4 weeks.
Students will receive a stipend for their research.
Unfortunately, we are not able to offer housing.
Career development, recreation, benefits, and compensation
The Karr Lab and Mount Sinai offer numerous opportunities for career development, as well as competitive benefits. Compensation will be commensurate with experience and education. Please see the links below for more information.
How to apply
Graduate students: Please email Jonathan a cover letter and CV, as well as apply to one of Mount Sinai's MS, MD, or PhD programs . PhD applications are due December 1 each year to start the following September.
Undergraduate students: Exceptional undergraduate students should email Jonathan a cover letter and CV and, if eligible, apply to the Mount Sinai Summer Undergraduate Research Program , the Systems Biology Center New York Summer Undergraduate Research Program , or the Mount Sinai Student Research Program .
Mount Sinai Medical Center is an equal opportunity/affirmative action employer.