Postdoctoral Fellow, Scientist, or graduate student in human whole-cell modeling

About the Karr Lab

Despite the explosion of experimental data, we do not understand the details of how phenotype arises from genotype and the environment. We are developing whole-cell computational models which comprehensively predict how cell behavior emerges from the molecular level by representing all of the biochemical activity inside cells. Our goal is to use whole-cell models to transform bioengineering and medicine into rigorous, quantitative disciplines. For example, we believe that whole-cell models could enable bioengineers to design microbial genomes for a variety of industrial applications, as well as enable physicians to tailor medical therapy to individual patients. Our research is highly interdisciplinary, involving systems biology, genomics, bioinformatics, data integration, parallel simulation, optimization, software engineering, and data visualization, and highly team-oriented.

About the Institute for Genomics & Multiscale Biology and the Icahn School of Medicine at Mount Sinai

The Icahn Institute for Genomics & Multiscale Biology is a leader in basic and translational genomic and computational biology research. The institute's multidisciplinary researchers bring state-of-the-art genomic technologies together with advanced computational analyses to discover new disease mechanisms, develop new diagnostics, and identify new drug targets. The institute is a highly collaborative and interdisciplinary environment. Please see the institute's website for more information.

The Icahn School of Medicine at Mount Sinai is a world leader in translational medicine. The school's multidisciplinary research institutes foster collaboration along a seamless continuum from the laboratory to patient care. State-of-the-art laboratories support groundbreaking research, and abundant clinical venues offer superb patient care and training.


The candidate will help develop the first whole-cell model of a human embryonic stem cell and use the model to gain insights into pluripotency maintenance among other fundamental cell behaviors. This will include aggregating and organizing experimental data to build models, designing models, calibrating models, validating models, analyzing simulation results, and using models to generate new hypotheses. The candidate will also have many opportunities to contribute to the development of new whole-cell modeling methods and tools. The candidate will work closely with our team at Mount Sinai.

Desired skills/experience

Whole-cell modeling is a highly challenging and interdisciplinary problem. Consequently, we are looking for creative scientists with strong experience in both computational science and biology who want to work with an interdisciplinary team. The ideal candidate has the following skills and experience. We also encourage applicants with related experience to apply.

  • BS, MS, or PhD in computational biology or related field;
  • Strong experience in dynamical and/or genome-scale modeling;
  • Broad knowledge of cell biology, genomics, mathematics, and computer programming;
  • Deep commitment to innovation and desire to tackle the most challenging problems;
  • Abilities to solve challenging problems by thinking creatively, integrating diverse concepts, and pushing through barriers;
  • Passion for transforming bioengineering and medicine;
  • Excellent oral and written communication skills; and
  • Abilities to work independently and within a team.

Career development, recreation, benefits, and compensation

The Karr Lab and Mount Sinai offer numerous opportunities for career development, as well as competitive benefits. Compensation will be commensurate with experience and education. Please see the links below for more information.

  • Staff
    • Benefits
    • Recreation
  • Postdoctoral scholars
    • Career development
    • Benefits
    • Subsidized housing
    • Recreation
    • Office of Postdoctoral Affairs
  • Graduate students
    • PhD and MS programs
    • Student organizations
    • Recreation
    • Subsidized housing

How to apply

Postdoctoral fellows and staff: Please email Jonathan a cover letter and CV.

Graduate students: Please email Jonathan a cover letter and CV, as well as apply to one of Mount Sinai's MS, MD, or PhD programs . PhD applications are due December 1 each year to start the following September.

Undergraduate students: Exceptional undergraduate students should email Jonathan a cover letter and CV and, if eligible, apply to the Mount Sinai Summer Undergraduate Research Program , the Systems Biology Center New York Summer Undergraduate Research Program , or the Mount Sinai Student Research Program .

High school students: Exceptional high school students should email Jonathan a cover letter and CV and, if eligible, apply to the Mount Sinai Student Research Program .

Mount Sinai Medical Center is an equal opportunity/affirmative action employer.

More information

Please contact Jonathan Karr .